I prefer pure Wine, as I like complete control over it's settings w/o any GUI cripplers.
But Wine has got so far that these days a barely need more than one prefix to run the stuff I need.
Sure, games are technically slower, sometimes more, sometimes less, but in case of older titles it simply doesn't matter, as Wine with today's hardware does the D3D -> OpenGL translation quite fast with those titles.
Well and if something goes wrong, one just deletes the prefix dir and by running winecfg, Windows is reinstalled.
That's why I keep all the software in general 'bin' dir on another dirve away from prefix, including Steam stuff, so I don't need to download it again.
Now, I'm not sure if the RCs of Wine 2.0 will build on CentOS7. Gonna try today just to be prepared.